The silent path to thousands of merozoites: the Plasmodium liver stage

M Prudêncio, A Rodriguez, MM Mota - Nature Reviews Microbiology, 2006 - nature.com
Plasmodium sporozoites are deposited in the skin of their vertebrate hosts through the bite
of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and …

Looking under the skin: the first steps in malarial infection and immunity

R Ménard, J Tavares, I Cockburn, M Markus… - Nature Reviews …, 2013 - nature.com
Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

Role of host cell traversal by the malaria sporozoite during liver infection

J Tavares, P Formaglio, S Thiberge… - Journal of experimental …, 2013 - rupress.org
Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into
the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a …

Revisiting the mechanisms of immune evasion employed by human parasites

M Chulanetra, W Chaicumpa - Frontiers in cellular and infection …, 2021 - frontiersin.org
For the establishment of a successful infection, ie, long-term parasitism and a complete life
cycle, parasites use various diverse mechanisms and factors, which they may be inherently …

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

MR Van Dijk, B Douradinha… - Proceedings of the …, 2005 - National Acad Sciences
Immunization with Plasmodium sporozoites that have been attenuated by γ-irradiation or
specific genetic modification can induce protective immunity against subsequent malaria …

Identification of a transcription factor in the mosquito‐invasive stage of malaria parasites

M Yuda, S Iwanaga, S Shigenobu… - Molecular …, 2009 - Wiley Online Library
Gene expression in Plasmodium parasites undergoes significant changes in each
developmental stage, but the transcription factors (TFs) regulating these changes have not …

Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity

E Lasonder, CJ Janse, GJ van Gemert, GR Mair… - PLoS …, 2008 - journals.plos.org
Plasmodium falciparum sporozoites that develop and mature inside an Anopheles mosquito
initiate a malaria infection in humans. Here we report the first proteomic comparison of …

Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma

J Baum, TW Gilberger, F Frischknecht, M Meissner - Trends in parasitology, 2008 - cell.com
Recent years have seen tremendous progress in our understanding of malaria parasite
molecular biology. To a large extent, this progress follows significant developments in …

Spreading the seeds of million-murdering death*: metamorphoses of malaria in the mosquito

LA Baton, LC Ranford-Cartwright - Trends in parasitology, 2005 - cell.com
Plasmodium spp. undergo a complex obligate developmental cycle within their invertebrate
vectors that enables transmission between vertebrate hosts. This developmental cycle …

How pathogens use linear motifs to perturb host cell networks

A Via, B Uyar, C Brun, A Zanzoni - Trends in biochemical sciences, 2015 - cell.com
Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their
hosts and take advantage of host cell functions to guarantee their replication and …