Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

The role of the anti-inflammatory cytokine interleukin-10 in tissue fibrosis

EH Steen, X Wang, S Balaji, MJ Butte… - Advances in wound …, 2020 - liebertpub.com
Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

[HTML][HTML] Hyaluronic acid and chondroitin sulfate (meth) acrylate-based hydrogels for tissue engineering: Synthesis, characteristics and pre-clinical evaluation

CCL Schuurmans, M Mihajlovic, C Hiemstra, K Ito… - Biomaterials, 2021 - Elsevier
Hydrogels based on photocrosslinkable Hyaluronic Acid Methacrylate (HAMA) and
Chondroitin Sulfate Methacrylate (CSMA) are presently under investigation for tissue …

Role of interleukins in the pathogenesis of pulmonary fibrosis

YX She, QY Yu, XX Tang - Cell Death Discovery, 2021 - nature.com
Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Toward a better regeneration through implant‐mediated immunomodulation: harnessing the immune responses

B Zhang, Y Su, J Zhou, Y Zheng, D Zhu - Advanced science, 2021 - Wiley Online Library
Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …

Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules

MI Rial-Hermida, A Rey-Rico… - ACS Biomaterials …, 2021 - ACS Publications
A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …

Novel drug delivery systems and disease models for pulmonary fibrosis

R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …