Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Mg 2+ is the most abundant divalent cation in metazoans and an essential cofactor for ATP,
nucleic acids, and countless metabolic enzymes. To understand how the spatio-temporal …

Mitochondrial structures were probably observed microscopically in the 1840s, but the idea
of oxidative phosphorylation (OXPHOS) within mitochondria did not appear until the 1930s …

MICU1 is a calcium (Ca2+)–binding protein that regulates the mitochondrial Ca2+ uniporter
channel complex (mtCU) and mitochondrial Ca2+ uptake. MICU1 knockout mice display …

Mitochondria form networks that continually remodel and adapt to carry out their cellular
function. The mitochondrial network is remodeled through changes in mitochondrial …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse …

Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …