Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …
However, developing drugs for central nervous system (CNS) disorders remains the most …
RNA-based therapies: A cog in the wheel of lung cancer defense
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
Adipocyte, immune cells, and miRNA crosstalk: a novel regulator of metabolic dysfunction and obesity
Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue
(AT) accompanied with alterations in the immune response that affects virtually all age and …
(AT) accompanied with alterations in the immune response that affects virtually all age and …
MiR-146a/b: a family with shared seeds and different roots
MR Paterson, AJ Kriegel - Physiological genomics, 2017 - journals.physiology.org
MicroRNAs are small, noncoding, RNAs known for their powerful modulation of molecular
processes, making them a major focus for studying pathological mechanisms. The human …
processes, making them a major focus for studying pathological mechanisms. The human …
Mir-21 suppression promotes mouse hepatocarcinogenesis
M Correia de Sousa, N Calo, C Sobolewski… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a frequent cancer of the liver with
limited therapeutic options. MicroRNAs are a class of small molecules regulating a wide …
limited therapeutic options. MicroRNAs are a class of small molecules regulating a wide …
Critical review of Epstein–Barr virus microRNAs relation with EBV‐associated gastric cancer
Abstract Epstein–Barr virus (EBV)‐associated gastric cancer (EBVaGC) is regarded as the
most prevalent malignant tumor triggered by EBV infection. In recent years, increasing …
most prevalent malignant tumor triggered by EBV infection. In recent years, increasing …
Rethinking bile acid metabolism and signaling for type 2 diabetes treatment
KE Zaborska, BP Cummings - Current Diabetes Reports, 2018 - Springer
Abstract Purpose of Review Herein, we review the role of FXR and TGR5 in the regulation of
hepatic bile acid metabolism, with a focus on how our understanding of bile acid metabolic …
hepatic bile acid metabolism, with a focus on how our understanding of bile acid metabolic …
Human cytomegalovirus (HCMV)-encoded microRNAs: potential biomarkers and clinical applications
R Fernández-Moreno, J Torre-Cisneros, S Cantisán - RNA biology, 2021 - Taylor & Francis
ABSTRACT HCMV-encoded microRNAs (hcmv-miRNAs) are non-coding and non-
immunogenic molecules that target numerous cellular genes and allow the virus to modulate …
immunogenic molecules that target numerous cellular genes and allow the virus to modulate …
The roles of EBV-encoded microRNAs in EBV-associated tumors
M Dong, J Chen, J Huang, L Gong, C Shao - Critical reviews in oncology …, 2019 - Elsevier
Epstein-Barr virus (EBV) is believed to be a pathogen causing a number of human cancers,
but the pathogenic mechanisms remain unclear. An increasing number of studies have …
but the pathogenic mechanisms remain unclear. An increasing number of studies have …
MicroRNAs in the spinal microglia serve critical roles in neuropathic pain
S Tang, H Jing, F Song, H Huang, W Li, G Xie… - Molecular …, 2021 - Springer
Neuropathic pain (NP) can occur after peripheral nerve injury (PNI), and it can be converted
into a maladaptive, detrimental phenotype that causes a long-term state of pain …
into a maladaptive, detrimental phenotype that causes a long-term state of pain …