As polymer networks infiltrated with water, hydrogels constitute the major components of the
human body; and hydrogels have been widely used in applications that closely interact with …

Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

Hydrogels have been developed since the 1960s for applications in personal care,
medicine, and engineering. Evidence has accumulated that hydrogels under prolonged …

Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

To investigate how substrate properties influence stem-cell fate, we cultured single human
epidermal stem cells on polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) hydrogel …

Interest in hydrogel materials is growing rapidly, due to the potential for hydrogel use in
tissue engineering and drug delivery applications, and as coatings on medical devices …

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at
which cellular shape changes can occur. Recent experimental evidence suggests that …

Transmission of mechanical force is crucial for normal cell development and functioning.
However, the process of mechanotransduction cannot be studied in isolation from cell …

Tough hydrogels of many chemical compositions have been developed in recent years, but
their fatigue fracture has not been studied. The lack of study hinders further development of …

Abstract Force-displacement (FZ) curves are the most commonly used Atomic Force
Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials …