The 25 years since the identification of the gene responsible for Huntington disease (HD)
have stood witness to profound discoveries about the nature of the disease and its …

Huntington Disease - GeneReviews® - NCBI Bookshelf US flag An official website of the United
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A major unresolved problem in neurodegenerative disease is why and how a specific set of
neurons in the brain are highly vulnerable to neuronal death. Multiple pathways and …

Objective Huntington disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by variable motor and behavioral symptoms attributed to major …

Objective A fundamental but still unresolved issue regarding Huntington disease (HD)
pathogenesis is whether the factors that determine age at onset are the same as those that …

Aims Huntington's disease (HD) is a progressive neurodegenerative disorder with
heterogeneous clinical manifestations. Identifying distinct clinical clusters and their relevant …

A major challenge in the treatment of neurodegenerative disorders is the translation of
effective therapies from the lab to the clinic. One approach to improve this process is the use …

Huntington's disease (HD) is caused by a CAG repeat expansion mutation in the gene
encoding the huntingtin (Htt) protein, with mutant Htt protein subsequently forming …

Emerging cellular and molecular studies are providing compelling evidence that altered
brain development contributes to the pathogenesis of Huntington's disease (HD). There has …

Purpose To scope the literature concerning irritability in Huntington's disease to determine
whether or not irritability is a valid and meaningful construct within this population. Method A …