During early post-natal life, neonates must adjust to the transition from the sheltered intra-
uterine environment to the microbe-laden external world, wherein they encounter a …

Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth,
and may be caused by several perinatal events. This medical condition affects some four …

The widespread introduction of therapeutic hypothermia as a standard of care in hypoxic–
ischemic encephalopathy (HIE) has brought increasing pressure on clinicians to make an …

To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide
(CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles …

The developing brain responds to injury in a gesta-tional age–dependent manner. During
the third trimester, white matter injury is most common, whereas in infants born at term, gray …

Brain damage related to perinatal asphyxia is the second cause of neuro-disability
worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide …

Vaccines have generally been developed with limited insight into their molecular impact.
While systems vaccinology enables characterization of mechanisms of action, these tools …

Objective To validate our previously identified candidate metabolites, and to assess the
ability of these metabolites to predict hypoxic-ischemic encephalopathy (HIE) both …

Perinatal asphyxia (PA) still occurs in about three to five per 1,000 deliveries in developed
countries; 20% of these infants show hypoxic-ischemic encephalopathy (HIE) on brain …

Ischemic brain injury provokes complex, time-dependent downstream pathways that
ultimately lead to cell death. We aimed to demonstrate the levels of a wide range of …