Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis

A Hinney, AL Volckmar, N Knoll - Progress in molecular biology and …, 2013 - Elsevier
The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular
genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 …

Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case–control Study and Meta‐analysis in 55,195 Individuals

D Wang, J Ma, S Zhang, A Hinney, J Hebebrand… - …, 2010 - Wiley Online Library
Recently, large‐scaled studies suggested a negative association of the infrequent allele of
the melanocortin‐4 receptor (MC4R) V103I polymorphism with obesity. We conducted a …

Melanocortin‐4 Receptor Gene Mutations in a Dutch Cohort of Obese Children

L Van Den Berg, O Van Beekum, P Heutink, BA Felius… - …, 2011 - Wiley Online Library
The most common monogenic form of obesity is caused by mutations in the gene encoding
the melanocortin‐4 receptor (MC4R). We have screened the MC4R coding sequence in 291 …

A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population

L Tao, Z Zhang, Z Chen, D Zhou, W Li, M Kan… - Molecular biology …, 2012 - Springer
A number of recent genome-wide association studies in European populations have
reported that variant rs17782313 is significantly associated with obesity and body mass …

Melanocortin-4 receptor gene polymorphisms in obese patients

E Yurtcu, A Yilmaz, Z Ozkurt, E Kolukisa, M Yilmaz… - Biochemical …, 2009 - Springer
Obesity is a complex disease caused by both genetics and environmental factors.
Melanocortin-4 receptor (MC4R)(MIM 155541) gene polymorphisms were reported to be the …

Waist-to-height ratio and obesity in chinese

CY Chou, Z Mao - Handbook of Anthropometry: Physical Measures of …, 2012 - Springer
Obesity is defined as a disease by the World Health Organization (WHO) and it increases
the risk of chronic diseases such as cardiovascular disease, hypertension, type 2 diabetes …