Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs)
have been the most extensively studied and widely used osteoinductive agents for clinical …

Objectives To systematically review the literature data regarding the critical size defect
(CSD) in adult rat calvaria and to determine which defect dimensions could be considered …

There is an urgent need to develop biomimetic bone tissue engineering scaffolds for the
repair of critical-sized calvarial defect. In this study, we developed a new nanoparticle …

Abstract Three-dimension (3D) porous reduced graphene oxide (RGO) scaffold has
attracted increasing attention in bone tissue engineering due to its favorable …

Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and
fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable …

The potential of growth factors to stimulate tissue healing through the enhancement of cell
proliferation, migration, and differentiation is undeniable. However, critical parameters on …

Injectable hydrogel systems are important bone substitutes for regeneration because of their
handling properties and the ability to fill irregular defects. Silk–hydroxyapatite composite …

Bone morphogenetic proteins (BMPs) are the most significant growth factors that belong to
the Transforming Growth Factor Beta (TGF-β) super-family. Though more than twenty …

DNA-based biomaterials have been proposed for tissue engineering approaches due to
their predictable assembly into complex morphologies and ease of functionalization. For …

Autogenous bone grafting remains a gold standard for the reconstruction critical‐sized bone
defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several …