Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Depression is a global health problem with growing prevalence rates and serious impacts
on the daily life of patients. However, the side effects of currently used antidepressants …

Increased inflammation in major depressive disorder (MDD) has been associated with low
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …

Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

Anhedonia, characterized by a lack of motivation, interest, or ability to experience pleasure,
is a prominent symptom of depression and other psychiatric disorders and has been …

Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness
(eg, depressive disorder, bipolar disorder, schizophrenia) that emerges during adolescence …

Background and purpose The paper observes regulation of the expression levels of NLRP3
and TLR4 in hippocampal CA1 neurons in CUMS mice by aerobic exercise with constructing …

In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have
emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated …