[HTML][HTML] Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

MS Kim, MJ Haney, Y Zhao, D Yuan, I Deygen… - … , Biology and Medicine, 2018 - Elsevier
Exosomes have recently emerged as a promising drug delivery system with low
immunogenicity, high biocompatibility, and high efficacy of delivery. We demonstrated …

Targeting metastasis

PS Steeg - Nature reviews cancer, 2016 - nature.com
Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

Extracellular vesicles for drug delivery

P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an
endogenous mechanism for intercellular communication. Since the discovery that EVs are …

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

MS Kim, MJ Haney, Y Zhao, V Mahajan… - … , Biology and Medicine, 2016 - Elsevier
Exosomes have recently come into focus as “natural nanoparticles” for use as drug delivery
vehicles. Our objective was to assess the feasibility of an exosome-based drug delivery …

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

PEM de Castilla, L Tong, C Huang, AM Sofias… - Advanced drug delivery …, 2021 - Elsevier
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

Exosome and exosomal microRNA: trafficking, sorting, and function

J Zhang, S Li, L Li, M Li, C Guo, J Yao… - Genomics, Proteomics …, 2015 - academic.oup.com
Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell
types into the extracellular space. Such vesicles are widely distributed in various body fluids …

Using exosomes, naturally-equipped nanocarriers, for drug delivery

EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …