[HTML][HTML] Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
Shedding light on extracellular vesicle biogenesis and bioengineering
F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations
Exosomes have recently emerged as a promising drug delivery system with low
immunogenicity, high biocompatibility, and high efficacy of delivery. We demonstrated …
immunogenicity, high biocompatibility, and high efficacy of delivery. We demonstrated …
Targeting metastasis
PS Steeg - Nature reviews cancer, 2016 - nature.com
Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …
Extracellular vesicles for drug delivery
P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Exosomes have recently come into focus as “natural nanoparticles” for use as drug delivery
vehicles. Our objective was to assess the feasibility of an exosome-based drug delivery …
vehicles. Our objective was to assess the feasibility of an exosome-based drug delivery …
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …
Exosome and exosomal microRNA: trafficking, sorting, and function
J Zhang, S Li, L Li, M Li, C Guo, J Yao… - Genomics, Proteomics …, 2015 - academic.oup.com
Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell
types into the extracellular space. Such vesicles are widely distributed in various body fluids …
types into the extracellular space. Such vesicles are widely distributed in various body fluids …
Using exosomes, naturally-equipped nanocarriers, for drug delivery
EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …
Re-engineering extracellular vesicles as smart nanoscale therapeutics
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …
the treatment of a range of pathologies, including cancer, myocardial infarction, and …