Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

B cell acute lymphoblastic leukemia (B-ALL) arises from genetic alterations impacting B cell
progenitors, ultimately leading to clinically overt disease. Extensive collaborative efforts in …

Studies have shown the power of transcriptome sequencing [RNA sequencing (RNA-Seq)]
in identifying known and novel oncogenic drivers and molecular subtypes of B-acute …

Improvements made during the last decades in the management of patients with
hematologic neoplasia have resulted in increase of overall survival. These advancements …

Sequencing of bulk tumor populations has improved genetic classification and risk
assessment of B-ALL, but does not directly examine intratumor heterogeneity or infer …

Cytogenetic analysis is mandatory at initial assessment of B-cell acute lymphoblastic
leukemia (B-ALL) due to its diagnostic and prognostic value. Results from chromosome …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) represents a
high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse …

We present a practical guide for analyzing the genetic aspects of lymphoblastic
leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) …

ABSTRACT Philadelphia-like (Ph-like) or BCR:: ABL1-like acute lymphoblastic leukemia
(ALL) is a common high-risk subtype of B-cell precursor ALL (B-ALL) characterized by a …

Progression of myeloproliferative neoplasms to blast phase (BPMPN) is associated with lack
of response to conventional therapies and dire clinical outcomes. Consequently, there is a …