Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

In recent years, the strategy for tumor therapy has changed from focusing on the direct killing
effect of different types of therapeutic agents on cancer cells to the new mainstream of multi …

Neoadjuvant immune-checkpoint blockade therapy only benefits a limited fraction of patients
with glioblastoma multiforme (GBM). Thus, targeting other immunomodulators on myeloid …

Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation
technique. Developing an understanding for the donor organ immune cell composition and …

Exercise can prevent osteoporosis and improve immune function, but the mechanism
remains unclear. Here, we show that exercise promotes reticulocalbin-2 secretion from the …

Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading
cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of …

Lung cancer remains the leading cause of cancer-related deaths globally, and the survival
rate remains low despite advances in diagnosis and treatment. The progression of lung …

Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …

EGLN3 is critically important for growth of various cancers including lung cancer. However,
virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in …

Exosomes are nanosized vesicles, derived from the endolysosomal compartment of cells
and can shuttle diverse biomolecules such as nucleic acids, proteins, lipids, amino acids …