Unlocking the promise of mRNA therapeutics
E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
The epitranscriptome beyond m6A
D Wiener, S Schwartz - Nature Reviews Genetics, 2021 - nature.com
Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …
Modifications in an emergency: the role of N1-methylpseudouridine in COVID-19 vaccines
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired
one of the most efficient vaccine development campaigns in human history. A key aspect of …
one of the most efficient vaccine development campaigns in human history. A key aspect of …
Self-assembled mRNA vaccines
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …
Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability
During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed
nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein …
nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein …
Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
Biological roles of RNA m5C modification and its implications in Cancer immunotherapy
H Song, J Zhang, B Liu, J Xu, B Cai, H Yang… - Biomarker …, 2022 - Springer
Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …