Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Acyl chain order parameter profiles in phospholipid bilayers: computation from molecular dynamics simulations and comparison with 2H NMR experiments
Order parameters from deuterium NMR are often used to validate or calibrate molecular
dynamics simulations. This paper gives a short overview of the literature in which …
dynamics simulations. This paper gives a short overview of the literature in which …
Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy
OC Andronesi, S Becker, K Seidel… - Journal of the …, 2005 - ACS Publications
It is shown that molecular structure and dynamics of a uniformly labeled membrane protein
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …
α-Helical transmembrane peptides: a “divide and conquer” approach to membrane proteins
N Bordag, S Keller - Chemistry and physics of lipids, 2010 - Elsevier
α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …
majority of drug targets. However, their relevance is in no way paralleled by our current …
Spectroscopic validation of the pentameric structure of phospholamban
NJ Traaseth, R Verardi, KD Torgersen… - Proceedings of the …, 2007 - National Acad Sciences
Phospholamban (PLN) regulates calcium translocation within cardiac myocytes by shifting
sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA) affinity for calcium. Although the …
sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA) affinity for calcium. Although the …
Bending elasticity of saturated and monounsaturated phospholipid membranes studied by the neutron spin echo technique
Z Yi, M Nagao, DP Bossev - Journal of Physics: Condensed …, 2009 - iopscience.iop.org
We have used neutron spin echo (NSE) spectroscopy to study the effect of bilayer thickness
and monounsaturation (existence of a single double bond on one of the aliphatic chains) on …
and monounsaturation (existence of a single double bond on one of the aliphatic chains) on …
Probing the interaction of polyphenols with lipid bilayers by solid-state NMR spectroscopy
X Yu, S Chu, AE Hagerman… - Journal of agricultural and …, 2011 - ACS Publications
Polyphenols are bioactive natural products that appear to act against a wide range of
pathologies. Mechanisms of activity have not been established, but recent studies have …
pathologies. Mechanisms of activity have not been established, but recent studies have …
Spectroscopic signatures of bilayer ordering in native biological membranes
Membrane proteins and polycyclic lipids like cholesterol and hopanoids coordinate
phospholipid bilayer ordering. This phenomenon manifests as partitioning of the liquid …
phospholipid bilayer ordering. This phenomenon manifests as partitioning of the liquid …
Quantifying binding of ethylene oxide–propylene oxide block copolymers with lipid bilayers
Block copolymers composed of poly (ethylene oxide)(PEO) and poly (propylene
oxide)(PPO) have been widely used in cell membrane stabilization and permeabilization. To …
oxide)(PPO) have been widely used in cell membrane stabilization and permeabilization. To …
Lipid Membrane Binding and Cell Protection Efficacy of Poly(1,2-butylene oxide)-b-poly(ethylene oxide) Copolymers
NJ Van Zee, AS Peroutka, A Crabtree… - …, 2022 - ACS Publications
Poloxamers consisting of poly (ethylene oxide)(PEO) and poly (propylene oxide) segments
can protect cell membranes against various forms of stress. We investigated the role of the …
can protect cell membranes against various forms of stress. We investigated the role of the …