Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Epithelial–mesenchymal transition (EMT) is a pivotal mechanism for cancer dissemination.
However, EMT-regulated individual cancer cell invasion is difficult to detect in clinical …

Acetylation is increasingly recognized as one of the major post-translational mechanisms for
the regulation of multiple cellular functions in mammalian cells. Acetyltransferase p300 …

Mutations in the type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause
pachyonychia congenita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic …

The ability of transcription factors to discriminate between different classes of binding sites
associated with specific biological functions underpins effective gene regulation in …

Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2
expression levels and transcriptional activity is important for bone morphogenetic protein …

The transcription factor MYC regulates cell proliferation, transformation, and survival in
response to growth factor signaling that is mediated in part by the kinase activity of ERK2 …

Background Microbial-associated molecular patterns activate several MAP kinases, which
are major regulators of the innate immune response in Arabidopsis thaliana that induce …

Although activating BRAF/NRAS mutations are frequently seen in melanomas, they are not
sufficient to drive malignant transformation and require additional events. Frequent co …