Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

Cryptic genetic variation (CGV) is invisible under normal conditions, but it can fuel evolution
when circumstances change. In theory, CGV can represent a massive cache of adaptive …

Human learning is a complex phenomenon requiring flexibility to adapt existing brain
function and precision in selecting new neurophysiological activities to drive desired …

Evolvability—the capacity to generate beneficial heritable variation—is a central property of
biological systems. However, its origins and modulation by environmental factors have not …

Robustness is characterized by the invariant expression of a phenotype in the face of a
genetic and/or environmental perturbation. Although phenotypic variance is a central …

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and
hypotheses on the key aspects of the evolution of life on earth in light of comparative …

The relationship between genotype (which is inherited) and phenotype (the target of
selection) is mediated by environmental inputs on gene expression, trait development, and …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental
understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal …

Nonsense-mediated mRNA decay (NMD) is a conserved RNA decay pathway that degrades
aberrant mRNAs and directly regulates many normal mRNAs. This dual role for NMD raises …