Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Traditional methods of cancer treatment are limited in their efficacy due to both inherent and
acquired factors. Many different studies have shown that the generation of ceramide in …

The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in
normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations …

Abstract Sphingosine kinase (SK) 1 and 2 are lipid kinases that catalyse the formation of
sphingosine 1-phosphate (S1P), a potent signalling molecule with a wide array of cellular …

Despite recent advances in the development of novel therapies against castration-resistant
prostate cancer, the advanced form of the disease remains a major treatment challenge …

Cancer development is a multistep process in which cells must overcome a series of
obstacles before they can become fully developed tumors. First, cells must develop the …