Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Depression is a common global mental disorder that seriously harms human physical and
mental health. With the development of society, the increase of pressure and the role of …

Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

As a widely-known neuropsychiatric disorder, the exact pathogenesis of depression remains
elusive. MiRNA-206 (miR-206) is conventionally known as one of the myomiRs and has two …

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

Introduction The most striking feature of depression is sadness and a loss of interest in
activities, which represents a major cause of disability globally. Therefore, it is necessary to …

Background Depression and dysosmia have been regarded as primary neurological
symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies …

Abstract MicroRNA-132/212 has been supposed as a critical gene related to the blood–
brain barrier (BBB) protection after stroke, but its regulation pathway including the upstream …

Purpose Microglia-neuron crosstalk is critically involved in synaptic plasticity and
degeneration by releasing diverse mediators in Alzheimer's disease (AD). Therefore …