Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Microbiota-derived metabolites as drivers of gut–brain communication

H Ahmed, Q Leyrolle, V Koistinen, O Kärkkäinen… - Gut …, 2022 - Taylor & Francis
Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

LG Costa, TB Cole, K Dao, YC Chang, J Coburn… - Pharmacology & …, 2020 - Elsevier
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and
cardiovascular diseases, may also negatively affect the brain and contribute to central …

[HTML][HTML] Trimethylamine N-oxide (TMAO) in human health

P Gatarek, J Kaluzna-Czaplinska - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and
diseases, this topic is very popular and is often taken up by researchers. TMAO is a low …

The gut microbiota and Alzheimer's disease

C Jiang, G Li, P Huang, Z Liu… - Journal of Alzheimer's …, 2017 - content.iospress.com
The gut microbiota comprises a complex community of microorganism species that resides
in our gastrointestinal ecosystem and whose alterations influence not only various gut …

Implications of gut microbiota in neurodegenerative diseases

H Zhang, Y Chen, Z Wang, G Xie, M Liu… - Frontiers in …, 2022 - frontiersin.org
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a
threat to the mental and physical quality of life of humans. The crucial effect of microbiota on …

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease

NM Vogt, KA Romano, BF Darst, CD Engelman… - Alzheimer's research & …, 2018 - Springer
Abstract Background Trimethylamine N-oxide (TMAO), a small molecule produced by the
metaorganismal metabolism of dietary choline, has been implicated in human disease …

Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease

Z Ou, L Deng, Z Lu, F Wu, W Liu, D Huang… - Nutrition & Diabetes, 2020 - nature.com
Objective Alzheimer's disease (AD) is a global health problem without effective methods to
alleviate the disease progression. Amyloid β-protein (Aβ) is widely accepted as a key …