The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
[HTML][HTML] Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
P Puchalska, PA Crawford - Cell metabolism, 2017 - cell.com
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
Polyhydroxyalkanoates: Trends and advances toward biotechnological applications
Plastics are an integral part of most of the daily requirements. Indiscriminate usage and
disposal have led to the accumulation of massive quantities of waste. Their non …
disposal have led to the accumulation of massive quantities of waste. Their non …
[HTML][HTML] Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule
S Chriett, A Dąbek, M Wojtala, H Vidal, A Balcerczyk… - Scientific reports, 2019 - nature.com
Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in
mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar …
mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar …
Microbial polyhydroxyalkanoates (PHAs): efficient replacement of synthetic polymers
Microbial polyhydroxyalkanoates (PHAs) are biopolyesters produced by microorganisms as
intracellular granules under nutrient stress. Due to non-toxic and biodegradable behavior …
intracellular granules under nutrient stress. Due to non-toxic and biodegradable behavior …
[HTML][HTML] Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases
Z Jiang, X Yin, M Wang, T Chen, Y Wang, Z Gao… - Aging and …, 2022 - ncbi.nlm.nih.gov
The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …
β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms
LB Achanta, CD Rae - Neurochemical research, 2017 - Springer
Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …
Ketone bodies mimic the life span extending properties of caloric restriction
RL Veech, PC Bradshaw, K Clarke, W Curtis… - IUBMB …, 2017 - Wiley Online Library
The extension of life span by caloric restriction has been studied across species from yeast
and Caenorhabditis elegans to primates. No generally accepted theory has been proposed …
and Caenorhabditis elegans to primates. No generally accepted theory has been proposed …
Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium–glucose cotransporter 2 inhibitors
M Packer - European journal of heart failure, 2020 - Wiley Online Library
In five large‐scale trials involving> 40 000 patients, sodium–glucose cotransporter 2
(SGLT2) inhibitors decreased the risk of serious heart failure events by 25–40%. This effect …
(SGLT2) inhibitors decreased the risk of serious heart failure events by 25–40%. This effect …
Cardiac-specific Bdh1 overexpression ameliorates oxidative stress and cardiac remodeling in pressure overload–induced heart failure
M Uchihashi, A Hoshino, Y Okawa… - Circulation: Heart …, 2017 - Am Heart Assoc
Background Energy starvation and the shift of energy substrate from fatty acids to glucose is
the hallmark of metabolic remodeling during heart failure progression. However, ketone …
the hallmark of metabolic remodeling during heart failure progression. However, ketone …