Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

Plastics are an integral part of most of the daily requirements. Indiscriminate usage and
disposal have led to the accumulation of massive quantities of waste. Their non …

Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in
mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar …

Microbial polyhydroxyalkanoates (PHAs) are biopolyesters produced by microorganisms as
intracellular granules under nutrient stress. Due to non-toxic and biodegradable behavior …

The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

The extension of life span by caloric restriction has been studied across species from yeast
and Caenorhabditis elegans to primates. No generally accepted theory has been proposed …

In five large‐scale trials involving> 40 000 patients, sodium–glucose cotransporter 2
(SGLT2) inhibitors decreased the risk of serious heart failure events by 25–40%. This effect …

Background Energy starvation and the shift of energy substrate from fatty acids to glucose is
the hallmark of metabolic remodeling during heart failure progression. However, ketone …