Knowing phylogenetic relationships among species is fundamental for many studies in
biology. An accurate phylogenetic tree underpins our understanding of the major transitions …

In addition to its value in the study of molecular evolution, ancestral sequence reconstruction
(ASR) has emerged as a useful methodology for engineering proteins with enhanced …

Natural proteins are often only slightly more stable in the native state than the denatured
state, and an increase in environmental temperature can easily shift the balance toward …

Natural enzymes are delicate biomolecules possessing only marginal thermodynamic
stability. Poorly stable, misfolded, and aggregated proteins lead to huge economic losses in …

With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the
computational challenge of efficiently and accurately constructing multiple genome …

Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain
capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is …

Confidence in molecular dating analyses has grown with the increasing sophistication of the
methods. Some problematic cases where molecular dates disagreed with paleontological …

Reconstructing the phylogenetic relationships between species is one of the most
formidable tasks in evolutionary biology. Multiple methods exist to reconstruct phylogenetic …

Throughout the history of life, enzymes have served as the primary molecular mediators of
biogeochemical cycles by catalyzing the metabolic pathways that interact with geochemical …

Antibiotics are central to modern medicine, and yet they are mainly the products of intra and
inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a …