Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
Androgen effects on the adrenergic system of the vascular, airway, and cardiac myocytes and their relevance in pathological processes
A Carbajal-García, J Reyes-García… - International Journal of …, 2020 - Wiley Online Library
Introduction. Androgen signaling comprises nongenomic and genomic pathways.
Nongenomic actions are not related to the binding of the androgen receptor (AR) and occur …
Nongenomic actions are not related to the binding of the androgen receptor (AR) and occur …
Hypoxia sensing of β-adrenergic receptor is regulated by endosomal PI3Kγ
Y Sun, K Stenson, ML Mohan, MK Gupta… - Circulation …, 2023 - Am Heart Assoc
Background: Impaired beta-adrenergic receptor (β1 and β2AR) function following hypoxia
underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide 3-kinase γ) by …
underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide 3-kinase γ) by …
Metabolomics meets clinics: a multivariate analysis of plasma and urine metabolic signatures in pulmonary arterial hypertension
R Wawrzyniak, P Grešner, E Lewicka… - Journal of Proteome …, 2023 - ACS Publications
Pulmonary arterial hypertension (PAH) is a severe, multifactorial, and frequently
misdiagnosed disorder. The aim of this observational study was to compare the plasma and …
misdiagnosed disorder. The aim of this observational study was to compare the plasma and …
Novel therapeutic targets for the treatment of right ventricular remodeling: insights from the pulmonary artery banding model
A Mamazhakypov, N Sommer, B Assmus… - International Journal of …, 2021 - mdpi.com
Right ventricular (RV) function is the main determinant of the outcome of patients with
pulmonary hypertension (PH). RV dysfunction develops gradually and worsens …
pulmonary hypertension (PH). RV dysfunction develops gradually and worsens …
CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics
H Xia, J Duan, M Li, N Chen, W Zhong, Y Zhou… - Journal of …, 2024 - Springer
Altered mitochondrial dynamics affect pulmonary artery endothelial cells (PAECs)
proliferation, contributing to the development of pulmonary hypertension. CD137 signaling …
proliferation, contributing to the development of pulmonary hypertension. CD137 signaling …
Taking it to heart: dissecting cardiopulmonary interactions in diseases of the lung and the cardiovascular system
T Lahm - American Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
World Heart Day, celebrated annually on September 29, was established by the World Heart
Federation to generate awareness of cardiovascular disease (CVD)(7). CVD truly is a global …
Federation to generate awareness of cardiovascular disease (CVD)(7). CVD truly is a global …
beta-blocker reverses inhibition of beta-2 adrenergic receptor resensitization by hypoxia
Y Sun, MK Gupta, K Stenson, ML Mohan, N Wanner… - bioRxiv, 2020 - biorxiv.org
Ischemia/hypoxia is major underlying cause for heart failure and stroke. Although beta-
adrenergic receptor (βAR) is phosphorylated in response to hypoxia, less is known about …
adrenergic receptor (βAR) is phosphorylated in response to hypoxia, less is known about …