▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …

Publisher Summary CD44 is a ubiquitous multistructural and multifunctional cell surface
adhesion molecule involved in cell–cell and cell–matrix interactions. CD44s is a single …

Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …

NK-92, a highly cytotoxic, interleukin-2 (IL-2)-dependent human natural killer (NK) cell line,
has been of interest for basic and translational research. We report on a comprehensive …

BACKGROUND Natural cytotoxicity, mediated by natural killer (NK) cells and cells with
lymphokine‐activated killer (LAK) activity, is believed to play an important role in host anti …

When once your point of view is changed, the very thing ADCC mediated by NK cells is
initiated by engagement which was so damning becomes a clue to the truth. of low-affinity Fc …

Lymphocyte CD44 interactions with hyaluronan localized on the endothelium have been
demonstrated to mediate rolling and regulate lymphocyte entry into sites of chronic …

In multicellular organisms the development of adhesion bonds, either among cells or among
cells and components of the extracellular matrix, is a crucial process. These interactions are …

CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine
diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic …

Unconjugated monoclonal antibodies have emerged as important therapeutic agents for
selected malignancies. One mechanism by which antibodies can exert cytotoxic effects is …