Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical
trials can fail for many reasons. This survey reviews many of these reasons and offers …

Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …

Background Loss of arm function is a common problem after stroke. Robot-assisted training
might improve arm function and activities of daily living. We compared the clinical …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

Background Substantial amounts of public funds are invested in health research worldwide.
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …

Background The current CONSORT guidelines for reporting pilot trials do not recommend
hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to …

Objective To determine whether, and to what extent, fall prevention exercise interventions for
older community dwelling people are effective in preventing different types of fall related …

Patient recruitment is widely recognized as a key determinant of success for clinical trials.
Yet a substantial number of trials fail to reach recruitment goals—a situation that has …

Background External pilot or feasibility studies can be used to estimate key unknown
parameters to inform the design of the definitive randomised controlled trial (RCT). However …

Background Recruiting the required number of participants is vital to the success of clinical
research and yet many studies fail to achieve their expected recruitment rate. Increasing …