Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer

K Tilekar, N Upadhyay, CV Iancu, V Pokrovsky… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Cancer research of the Warburg effect, a hallmark metabolic alteration in tumors, focused
attention on glucose metabolism whose targeting uncovered several agents with promising …

Antitumor activity of alloy and core-shell-type bimetallic AgAu nanoparticles

I Shmarakov, I Mukha, N Vityuk… - Nanoscale research …, 2017 - Springer
Nanoparticles (NPs) of noble metals, namely gold and silver, remain promising anticancer
agents capable of enhancing current surgery-and chemotherapeutic-based approaches in …

Streptomyces nigra sp. nov. Is a Novel Actinobacterium Isolated From Mangrove Soil and Exerts a Potent Antitumor Activity in Vitro

C Chen, Y Ye, R Wang, Y Zhang, C Wu… - Frontiers in …, 2018 - frontiersin.org
A new bacterial strain, designated 452T, was isolated from the rhizosphere soil of the
mangrove Avicennia marina in China. As determined, its cell wall peptidoglycan contained ll …

p53-Mediated Indirect regulation on Cellular metabolism: from the mechanism of pathogenesis to the development of cancer therapeutics

CY Wang, CH Chao - Frontiers in Oncology, 2022 - frontiersin.org
The transcription factor p53 is the most well-characterized tumor suppressor involved in
multiple cellular processes, which has expanded to the regulation of metabolism in recent …

Dual hyaluronic acid and folic acid targeting pH-sensitive multifunctional 2DG@ DCA@ MgO-Nano-Core–Shell-Radiosensitizer for breast cancer therapy

MA Askar, NM Thabet, GS El-Sayyad, AI El-Batal… - Cancers, 2021 - mdpi.com
Simple Summary In this study, we have developed CD44 and folate receptor-targeting multi-
functional dual drug-loaded nanoparticles. This comprises hyaluronic acid (HA) and folic …

Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and …

NM Thabet, MK Abdel-Rafei, GS El-Sayyad… - Cancer …, 2022 - Springer
Background Tumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of
cancer cell growth. This study is designed to combine the newly synthesized two …

Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis

SM El Sayed, H Baghdadi, NS Ahmed… - Medical hypotheses, 2019 - Elsevier
Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with
chemoresistant non-Hodgkin's lymphoma and treated lactic acidosis effectively. The well …

Mitochondrial dysfunction of peripheral blood mononuclear cells is associated with lung carcinogenesis

W Liu, H Li, Y Gao, X Zhang, Z Wei, D Yang… - International …, 2024 - Elsevier
The composition, quantity, and function of peripheral blood mononuclear cells (PBMCs) are
closely correlated with tumorigenesis. However, the mechanisms of PBMCs in lung cancer …

MITOCHONDRIAL DYSFUNCTION SIGNIFICANTLY CONTRIBUTES TO THE SENSITIVITY OF TUMOR CELLS TO ANOIKIS AND THEIR METASTATIC POTENTIAL

GI Solyanik, DL Kolesnik, IV Prokhorova… - Heliyon, 2024 - cell.com
It is well-known that the survival of metastatic cells during their dissemination plays an
important role in metastasis. However, does this mean that the final result of the metastatic …

Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts

T Koltai, L Fliegel - Pharmaceuticals, 2024 - mdpi.com
Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was
initially considered a dangerous toxic industrial waste product, then a potential treatment for …