Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

The cilium is an antenna-like organelle that performs numerous cellular functions, including
motility, sensing, and signaling. The base of the cilium contains a selective barrier that …

Expansion microscopy (ExM) is a highly effective technique for super-resolution
fluorescence microscopy that enables imaging of biological samples beyond the diffraction …

Cryofixation has proven to be the gold standard for efficient preservation of native cell
ultrastructure compared to chemical fixation, but this approach is not widely used in …

Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

Cryo-electron tomography (cryo-ET) has become a powerful approach to study the high-
resolution structure of cellular macromolecular machines in situ. However, the current …

The basal complex (BC) is essential for T. gondii cell division but mechanistic details are
lacking. Here we report a reciprocal proximity based biotinylation approach to map the BC's …

Motile cilia are molecular machines used by a myriad of eukaryotic cells to swim through
fluid environments. However, available molecular structures represent only a handful of cell …

Expansion microscopy (ExM) physically magnifies specimens, allowing to obtain super-
resolution images using a conventional diffraction-limited microscope such as confocal …