Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation
JV Reddy, K Raudenbush, ET Papoutsakis… - Biotechnology …, 2023 - Elsevier
In order to meet the rising demand for biologics and become competitive on the developing
biosimilar market, there is a need for process intensification of biomanufacturing processes …
biosimilar market, there is a need for process intensification of biomanufacturing processes …
[HTML][HTML] Genome-scale models as a vehicle for knowledge transfer from microbial to mammalian cell systems
B Strain, J Morrissey, A Antonakoudis… - Computational and …, 2023 - Elsevier
With the plethora of omics data becoming available for mammalian cell and, increasingly,
human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful …
human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful …
How reliable are Chinese hamster ovary (CHO) cell genome‐scale metabolic models?
B Strain, J Morrissey, A Antonakoudis… - Biotechnology and …, 2023 - Wiley Online Library
Genome‐scale metabolic models (GEMs) possess the power to revolutionize bioprocess
and cell line engineering workflows thanks to their ability to predict and understand whole …
and cell line engineering workflows thanks to their ability to predict and understand whole …
[HTML][HTML] Towards rational glyco-engineering in CHO: from data to predictive models
J Štor, DE Ruckerbauer, D Széliová… - Current Opinion in …, 2021 - Elsevier
Metabolic modelling strives to develop modelling approaches that are robust and highly
predictive. To achieve this, various modelling designs, including hybrid models, and …
predictive. To achieve this, various modelling designs, including hybrid models, and …
[HTML][HTML] Inclusion of maintenance energy improves the intracellular flux predictions of CHO
D Széliová, J Štor, I Thiel, M Weinguny… - PLoS Computational …, 2021 - journals.plos.org
Chinese hamster ovary (CHO) cells are the leading platform for the production of
biopharmaceuticals with human-like glycosylation. The standard practice for cell line …
biopharmaceuticals with human-like glycosylation. The standard practice for cell line …
[PDF][PDF] Metabolic Modeling in Practice: Advancing Biotechnological Production and Metabolome Data Analysis
DIM Gotsmy - 2023 - phaidra.univie.ac.at
Metabolic models serve a dual purpose in understanding biological systems:(1) decoding
mechanistic relationships after experimental data acquisition; and (2) acting as predictive …
mechanistic relationships after experimental data acquisition; and (2) acting as predictive …