Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …

Since the pioneering work of Gowans and colleagues in the 1960s, 1, 2 much progress has
been made in understanding the pivotal role of cell migration in immunity. We now have …

Chemokines and their receptors are central to the inflammatory process and are attractive
therapeutic targets. Drugs that inhibit chemokine receptors are approved for the treatment of …

Eosinophil infiltration into the esophagus is observed in diverse diseases including
gastroesophageal reflux and allergic gastroenteritis, but the processes involved are largely …

Asthma is a triad of intermittent airway obstruction, bronchial smooth muscle cell
hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. From an …

BACKGROUND & AIMS:: Eosinophil infiltration into the esophagus occurs in a wide range of
diseases; however, the underlying pathophysiologic mechanisms involved are largely …

Background: IL-13 induces several characteristic features of asthma, including airway
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the …

Eosinophil infiltration into the esophagus occurs in a wide range of diseases; however, the
underlying pathophysiological mechanisms involved are largely unknown. We now report …

The prevalence of asthma has risen drastically in the last two decades, with a worldwide
impact on health care systems. Although several factors contribute to the development of …