Recently, developmental systems are investigated with increasing technological power. Still,
open questions remain, especially concerning self-organization capacity and its control …

Endothelial cells display an extraordinary plasticity both during development and throughout
adult life. During early development, endothelial cells assume arterial, venous, or lymphatic …

Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic
disorders. In addition, the generation of ECs has become increasingly important for …

Rationale: Direct conversion or reprogramming of human postnatal cells into endothelial
cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine …

Cell fate decisions involved in vascular and hematopoietic embryonic development are still
poorly understood. An ETS transcription factor Etv2 functions as an evolutionarily conserved …

Mesoderm induction begins during gastrulation. Recent evidence from several vertebrate
species indicates that mesoderm induction continues after gastrulation in neuromesodermal …

The cerebral vasculature provides the massive blood supply that the brain needs to grow
and survive. By acquiring distinctive cellular and molecular characteristics it becomes the …

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and
functional features of specific organs. Because of these characteristics, organoids have …

Sonic hedgehog (Shh) is essential for limb development, and the mechanisms that govern
the propagation and maintenance of its expression has been well studied; however, the …

The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage
determination have been a focus of intense interest, and have been investigated in various …