Background Metformin is an oral anti‐hyperglycemic agent that has been shown to reduce
total mortality compared to other anti‐hyperglycemic agents, in the treatment of type 2 …

Metformin is now established as a first-line antidiabetic therapy for the management of type
2 diabetes. Its early use in treatment algorithms is supported by lack of weight gain, low risk …

Aims Sodium–glucose co‐transporter 2 (SGLT2) reabsorbs glucose and sodium in the renal
proximal tubule. Dapagliflozin, an SGLT2 inhibitor, targets hyperglycaemia in type 2 …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on oral pharmacologic treatment of type …

Context Metformin is the recommended initial drug therapy for patients with type 2 diabetes
mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is …

This article has been corrected. The original version (PDF) is appended to this article as a
supplement. Description: The American College of Physicians (ACP) developed this …

Aims/hypothesis Sulfonylureas are widely prescribed glucose-lowering medications for
diabetes, but the extent to which they improve glycaemia is poorly documented. This …

Introduction When first line therapy with metformin is insufficient for patients with type 2
diabetes (T2D), the optimal adjunctive therapy is unclear. We assessed the efficacy and …

Aim: Most guidelines recommend metformin as first‐line therapy in patients with type 2
diabetes. However, the choice of a second‐line drug lacks consistent consensus. We aimed …

BACKGROUND AND AIMS: To investigate the impact of a diet modeled on the traditional
Cretan Mediterranean diet on metabolic control and vascular risk in type 2 diabetes …