CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
Biological consequences of MHC-II expression by tumor cells in cancer
Immunotherapy has emerged as a key pillar of cancer treatment. To build upon the recent
successes of immunotherapy, intense research efforts are aimed at a molecular …
successes of immunotherapy, intense research efforts are aimed at a molecular …
Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy
with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the …
with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the …
The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma
J Nagasaki, Y Togashi, T Sugawara, M Itami… - Blood …, 2020 - ashpublications.org
Classic Hodgkin lymphoma (cHL) responds markedly to PD-1 blockade therapy, and the
clinical responses are reportedly dependent on expression of major histocompatibility …
clinical responses are reportedly dependent on expression of major histocompatibility …
[HTML][HTML] Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis
J Yan, L Zhou, M Liu, H Zhu, X Zhang, E Cai, X Xu… - Cell Reports, 2024 - cell.com
Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary,
causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing …
causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing …
A variety of 'exhausted'T cells in the tumor microenvironment
J Nagasaki, Y Togashi - International Immunology, 2022 - academic.oup.com
In T-cell biology,'exhaustion'was initially described as a hyporesponsive state in CD8+ T
cells during chronic infections. Recently, exhaustion has been recognized as a T-cell …
cells during chronic infections. Recently, exhaustion has been recognized as a T-cell …
Human leukocyte antigen and tumor immunotherapy
DH Liu, FF Mou, M An, P Xia - … Journal of Oncology, 2023 - spandidos-publications.com
Malignant tumors seriously endanger human health and life, and restrict economic
development. Human leukocyte antigen (HLA) is the expression product of the human major …
development. Human leukocyte antigen (HLA) is the expression product of the human major …
Amateur antigen‐presenting cells in the tumor microenvironment
LB Darragh, SD Karam - Molecular carcinogenesis, 2022 - Wiley Online Library
Presentation of tumor antigens is a critical step in producing a robust antitumor immune
response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T …
response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T …
Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and …
D Liu, P Hofman - Cellular Oncology, 2022 - Springer
Purpose Reliable biomarkers to predict the outcome and treatment response of estrogen
receptor (ER)-negative breast cancer (BC) are urgently needed. Since immune-related …
receptor (ER)-negative breast cancer (BC) are urgently needed. Since immune-related …
The interplay between immunity and microbiota at intestinal immunological niche: the case of cancer
The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune
diseases. While multiple mechanisms are involved, the immune system clearly plays a …
diseases. While multiple mechanisms are involved, the immune system clearly plays a …