Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

[HTML][HTML] miRNA clusters with down-regulated expression in human colorectal cancer and their regulation

P Pidíkova, R Reis, I Herichova - International journal of molecular …, 2020 - mdpi.com
Regulation of microRNA (miRNA) expression has been extensively studied with respect to
colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality …

CARMN Is an Evolutionarily Conserved Smooth Muscle Cell–Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin

K Dong, J Shen, X He, G Hu, L Wang, I Osman… - Circulation, 2021 - Am Heart Assoc
Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …

CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

F Vacante, J Rodor, MK Lalwani, AD Mahmoud… - Circulation …, 2021 - Am Heart Assoc
Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …

[HTML][HTML] The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease

F Vacante, L Denby, JC Sluimer, AH Baker - Vascular Pharmacology, 2019 - Elsevier
Abstract Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical
modulators of phenotypic changes associated with physiological and pathological contexts …

[HTML][HTML] Association of endometriosis with cardiovascular disease: Genetic aspects

VM Vazgiourakis, MI Zervou… - International …, 2023 - spandidos-publications.com
Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that
affect the heart or blood vessels, including sequelae that arise from damaged vasculature in …

[HTML][HTML] A transcribed enhancer dictates mesendoderm specification in pluripotency

M Alexanian, D Maric, SP Jenkinson, M Mina… - Nature …, 2017 - nature.com
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage
specification during development. Here, we evaluate remodeling of the enhancer landscape …

The Notch pathway: a novel therapeutic target for cardiovascular diseases?

G Aquila, A Kostina, F Vieceli Dalla Sega… - Expert opinion on …, 2019 - Taylor & Francis
ABSTRACT Introduction: The Notch pathway is involved in determining cell fate during
development and postnatally in continuously renewing tissues, such as the endothelium, the …

Noncoding RNAs: biology and applications—a Keystone Symposia report

J Cable, E Heard, T Hirose, KV Prasanth… - Annals of the new …, 2021 - Wiley Online Library
The human transcriptome contains many types of noncoding RNAs, which rival the number
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …

A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification

I Plaisance, P Chouvardas, Y Sun… - Cardiovascular …, 2023 - academic.oup.com
Aims The major cardiac cell types composing the adult heart arise from common multipotent
precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous …