Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
[HTML][HTML] miRNA clusters with down-regulated expression in human colorectal cancer and their regulation
P Pidíkova, R Reis, I Herichova - International journal of molecular …, 2020 - mdpi.com
Regulation of microRNA (miRNA) expression has been extensively studied with respect to
colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality …
colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality …
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell–Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin
Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
F Vacante, J Rodor, MK Lalwani, AD Mahmoud… - Circulation …, 2021 - Am Heart Assoc
Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …
[HTML][HTML] The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease
Abstract Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical
modulators of phenotypic changes associated with physiological and pathological contexts …
modulators of phenotypic changes associated with physiological and pathological contexts …
[HTML][HTML] Association of endometriosis with cardiovascular disease: Genetic aspects
VM Vazgiourakis, MI Zervou… - International …, 2023 - spandidos-publications.com
Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that
affect the heart or blood vessels, including sequelae that arise from damaged vasculature in …
affect the heart or blood vessels, including sequelae that arise from damaged vasculature in …
[HTML][HTML] A transcribed enhancer dictates mesendoderm specification in pluripotency
M Alexanian, D Maric, SP Jenkinson, M Mina… - Nature …, 2017 - nature.com
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage
specification during development. Here, we evaluate remodeling of the enhancer landscape …
specification during development. Here, we evaluate remodeling of the enhancer landscape …
The Notch pathway: a novel therapeutic target for cardiovascular diseases?
ABSTRACT Introduction: The Notch pathway is involved in determining cell fate during
development and postnatally in continuously renewing tissues, such as the endothelium, the …
development and postnatally in continuously renewing tissues, such as the endothelium, the …
Noncoding RNAs: biology and applications—a Keystone Symposia report
The human transcriptome contains many types of noncoding RNAs, which rival the number
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …
A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification
I Plaisance, P Chouvardas, Y Sun… - Cardiovascular …, 2023 - academic.oup.com
Aims The major cardiac cell types composing the adult heart arise from common multipotent
precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous …
precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous …