The rates of asthma and obesity are increasing concurrently in the United States.
Epidemiologic studies demonstrate that the incidence of asthma increases with obesity …

Sirtuins are NAD-dependent class III histone deacetylase, which modulate the epigenetic
changes to influence the functions in normal and diseased conditions. Preclinical studies …

Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is
higher in people with asthma than in the general population. Obese people often have …

Background: Asthma is a chronic airway disease, affecting over 300 million people
worldwide. 5–10% of patients suffer from severe asthma and account for 50% of asthma …

Obesity is associated with increased severity of asthma. Bariatric surgery can be effective in
weight loss and improvement in asthma. Two reviewers conducted a systematic review …

Increased insulin is associated with obesity-related airway hyperreactivity and asthma. We
tested whether the use of metformin, an antidiabetic drug used to reduce insulin resistance …

Background Obesity is often associated with uncontrolled, difficult-to-treat asthma and
increased morbidity and mortality. Previous studies suggest that weight loss may improve …

Background Many patients with severe asthma are overweight or obese, often attributed to
unintentional weight gain as a side effect of oral corticosteroids (OCSs). Anti–IL-5/5Ra …

Recognition of obesity as a treatable trait of asthma, impacting its development, clinical
presentation and management, is gaining widespread acceptance. Obesity is a significant …

Interventions Because obesity-associated asthma is less responsive to typical asthma
medications, an integrated approach to the patient with comorbid obesity requires attention …