Newer treatment strategy based on proliferative nuclear marker Ki-67 targeted therapy holds
promise for prioritized/personalized treatment options with regard to improved survival and …

Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …

DNA microarray technology has emerged as a prospective tool for diagnosis of cancer and
its classification. It provides better insights of many genetic mutations occurring within a cell …

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that
disproportionately affects BRCA1 mutation carriers and young women of African origin …

Breast cancer is a complex and heterogeneous disease. Gene expression profiling has
contributed significantly to our understanding of this heterogeneity at a molecular level …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

The sequence of the human genome has dramatically accelerated biomedical research.
Here I explore its impact, in the decade since its publication, on our understanding of the …

Background Gene expression profiling of breast cancer has identified two biologically
distinct estrogen receptor (ER)-positive subtypes of breast cancer: luminal A and luminal B …

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …

Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, lymph …