[HTML][HTML] Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases

A Henriquez-Figuereo, C Morán-Serradilla… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

Multi-and poly-pharmacology of carbonic anhydrase inhibitors

CT Supuran - Pharmacological Reviews, 2024 - Elsevier
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …

Preparation of celery essential oil-based nanoemulsion by ultrasonication and evaluation of its potential anticancer and antibacterial activity

MJ Nirmala, L Durai, V Gopakumar… - International Journal of …, 2020 - Taylor & Francis
Introduction Plants have always been a significant source of natural active components with
biological properties. Celery seed oil (extracted from Apium graveolens) has several …

Carbon-versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2018 - Taylor & Francis
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …

Ultrasonic Nanoemulsification of Cuminum cyminum Essential Oil and Its Applications in Medicine

MJ Nirmala, L Durai, KA Rao… - International journal of …, 2020 - Taylor & Francis
Background and Study Cumin seed oil (extracted from Cuminum cyminum) has many
applications but conclusive evidence of its therapeutic uses has not been presented. This …

Why hasn't there been more progress in new Chagas disease drug discovery?

AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …

Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods: Investigation on anticancer, wound healing, and antibacterial effects

K Shanmugapriya, H Kim, PS Saravana… - Colloids and Surfaces B …, 2018 - Elsevier
Emulsion-based delivery systems have been fabricated and developed to increase the
bioavailability of astaxanthin and alpha-tocopherol as active compounds for various …

Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment

R Tiwari, RP Gupta, VK Singh, A Kumar, Rajneesh… - ACS …, 2023 - ACS Publications
Parasitic infections are a major global health issue causing significant mortality and
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …

4-(3-Alkyl/benzyl-guanidino) benzenesulfonamides as selective carbonic anhydrase VII inhibitors

M Abdoli, S Giovannuzzi, CT Supuran… - Journal of Enzyme …, 2022 - Taylor & Francis
The treatment of chronic neuropathic pain remains one of the most challenging of all
neurological diseases and very much an art. There exists no consensus for the optimal …

From Benznidazole to new drugs: Nanotechnology contribution in Chagas disease

DC Gomes, TS Medeiros, EL Alves Pereira… - International Journal of …, 2023 - mdpi.com
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …