[HTML][HTML] Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
A Henriquez-Figuereo, C Morán-Serradilla… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
protozoan etiology, high incidence, and prevalence in developing countries. As a result …
Multi-and poly-pharmacology of carbonic anhydrase inhibitors
CT Supuran - Pharmacological Reviews, 2024 - Elsevier
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
Preparation of celery essential oil-based nanoemulsion by ultrasonication and evaluation of its potential anticancer and antibacterial activity
MJ Nirmala, L Durai, V Gopakumar… - International Journal of …, 2020 - Taylor & Francis
Introduction Plants have always been a significant source of natural active components with
biological properties. Celery seed oil (extracted from Apium graveolens) has several …
biological properties. Celery seed oil (extracted from Apium graveolens) has several …
Carbon-versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2018 - Taylor & Francis
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …
Ultrasonic Nanoemulsification of Cuminum cyminum Essential Oil and Its Applications in Medicine
MJ Nirmala, L Durai, KA Rao… - International journal of …, 2020 - Taylor & Francis
Background and Study Cumin seed oil (extracted from Cuminum cyminum) has many
applications but conclusive evidence of its therapeutic uses has not been presented. This …
applications but conclusive evidence of its therapeutic uses has not been presented. This …
Why hasn't there been more progress in new Chagas disease drug discovery?
AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …
Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods: Investigation on anticancer, wound healing, and antibacterial effects
K Shanmugapriya, H Kim, PS Saravana… - Colloids and Surfaces B …, 2018 - Elsevier
Emulsion-based delivery systems have been fabricated and developed to increase the
bioavailability of astaxanthin and alpha-tocopherol as active compounds for various …
bioavailability of astaxanthin and alpha-tocopherol as active compounds for various …
Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment
Parasitic infections are a major global health issue causing significant mortality and
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …
4-(3-Alkyl/benzyl-guanidino) benzenesulfonamides as selective carbonic anhydrase VII inhibitors
The treatment of chronic neuropathic pain remains one of the most challenging of all
neurological diseases and very much an art. There exists no consensus for the optimal …
neurological diseases and very much an art. There exists no consensus for the optimal …
From Benznidazole to new drugs: Nanotechnology contribution in Chagas disease
DC Gomes, TS Medeiros, EL Alves Pereira… - International Journal of …, 2023 - mdpi.com
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …