Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most
important advance in sleep research and sleep medicine since the discovery of rapid eye …

Type 1 diabetes mellitus (T1D) is a chronic, multifactorial autoimmune disease that involves
the progressive destruction of pancreatic β-cells, ultimately resulting in the loss of insulin …

Islet transplantation is considered as an ultimate option for the treatment of type I diabetes.
Human induced pluripotent stem cells (hiPSCs) have raised the possibility that patient …

Mouse and human induced pluripotent stem cells (iPSCs) may represent a novel approach
for modeling diabetes. Taking this into consideration, the aim of this study was to generate …

Type 1 diabetes mellitus is an autoimmune disease resulting from the destruction of insulin-
producing pancreatic β-cells. Cell-based therapies, involving the transplantation of …

At present, the number of diabetes patients has exceeded 537 million worldwide and this
number continues to increase. Stem cell therapy represents a new direction for the treatment …

Highlights•Limitations of virtual drug screening and rational drug design.•The evolutionary
basis of drug discovery.•The power of predictive bioanalytics and the CANDO …

Diabetes mellitus is the most prevailing disease with progressive incidence worldwide. To
date, the pathogenesis of diabetes is far to be understood, and there is no permanent …

The successful landmark discovery of mouse and human inducible pluripotential stem cells
(iPSC's) by Takahashi and Yamanaka in 2006 and 2007 has triggered a revolution in the …