Redox-controlled chemical protein synthesis: sundry shades of latency

V Agouridas, N Ollivier, J Vicogne… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus The last two decades have witnessed the rise in power of chemical protein
synthesis to the point where it now constitutes an established corpus of synthetic methods …

A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification

N Ollivier, M Sénéchal, R Desmet, B Snella… - Nature …, 2022 - nature.com
The modification of protein electrostatics by phosphorylation is a mechanism used by cells to
promote the association of proteins with other biomolecules. In this work, we show that …

Incorporation of a Highly Reactive Oxalyl Thioester-Based Interacting Handle into Proteins

B Grain, R Desmet, B Snella, O Melnyk… - Organic …, 2023 - ACS Publications
Providing biomolecules with extended physicochemical, biochemical, or biological
properties is a contemporary challenge motivated by impactful benefits in life or materials …

Chemical Modification of Peptides and Proteins Using Spirooxindole Oxirane Derivatives

SS Chavan, H Saze, F Tanaka - Advanced Synthesis & …, 2023 - Wiley Online Library
Methods for chemical modification of proteins and peptides at certain positions are required
for the preparation of antibody‐drug conjugates, protein‐or peptide‐biotin conjugates, and …

[PDF][PDF] Fast-SEA: Modifying Proteins in the Nanomolar Concentration Range with an NCL Inspired Ligation

B Grain, B Snella, J Vicogne, B Wiltschi, O Melnyk… - 2022 - kvinzo.com
Chemical Protein Synthesis has greatly benefitted from the properties of the thioester
functional group, in particular with the development of the Native Chemical Ligation (NCL) …