The effect of the novel tellurium compound AS101 on autoimmune diseases

G Halpert, B Sredni - Autoimmunity reviews, 2014 - Elsevier
Tellurium is a rare element, which has been regarded as a non-essential trace element
despite its relative abundance in the human body. The chemistry of tellurium supports a …

Tracing tellurium and its nanostructures in biology

B Zare, M Nami, AR Shahverdi - Biological trace element research, 2017 - Springer
Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and
selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te …

[HTML][HTML] p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium

L Wang, M Cano, JT Handa - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
As a signaling hub, p62/sequestosome plays important roles in cell signaling and
degradation of misfolded proteins. p62 has been implicated as an adaptor protein to …

[HTML][HTML] Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells

X Chen, R Han, P Hao, L Wang, M Liu, M Jin… - Biomedicine & …, 2018 - Elsevier
Backgrounds Chronic inflammation in retinal pigment epithelial (RPE) cells is related to the
pathogenesis of retinal inflammatory blind causing diseases such as age-related macular …

The natural carotenoid crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial …

G Di Emidio, G Rossi, I Bonomo… - Oxidative medicine …, 2017 - Wiley Online Library
Cancer therapies are associated with increased infertility risk due to accelerated
reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity …

Screening of AS101 analog, organotellurolate (IV) compound 2 for its in vitro biocompatibility, anticancer, and antibacterial activities

A Tripathi, A Khan, P Kiran, H Shetty, R Srivastava - Amino Acids, 2023 - Springer
Organotellurium compounds are being well researched as potential candidates for their
functional roles in therapeutic and clinical biology. Here, we report the in vitro anticancer …

Illumination from light-emitting diodes (LEDs) disrupts pathological cytokines expression and activates relevant signal pathways in primary human retinal pigment …

Y Shen, C Xie, Y Gu, X Li, J Tong - Experimental eye research, 2016 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness in the aged
people. The latest systemic review of epidemiological investigations revealed that excessive …

Medicinal hypervalent tellurium prodrugs bearing different ligands: a comparative study of the chemical profiles of AS101 and its halido replaced analogues

L Chiaverini, D Cirri, I Tolbatov, F Corsi, I Piano… - International Journal of …, 2022 - mdpi.com
Ammonium trichloro (dioxoethylene-O, O′) tellurate (AS101) is a potent immunomodulator
prodrug that, in recent years, entered various clinical trials and was tested for a variety of …

Elucidation of tellurium biogenic nanoparticles in garlic, Allium sativum, by inductively coupled plasma-mass spectrometry

Y Tanaka, S Takada, K Kumagai, K Kobayashi… - Journal of Trace …, 2020 - Elsevier
Abstract Background Biosynthesis of Te nanoparticles may occur in higher plants exposed
to Te, as reported on microorganisms. However, unambiguous observations of the biogenic …

[HTML][HTML] Unveiling the mechanism of activation of the Te (IV) prodrug AS101. New chemical insights towards a better understanding of its medicinal properties

L Chiaverini, I Tolbatov, A Marrone, T Marzo… - Journal of Inorganic …, 2024 - Elsevier
Abstract AS101 (Ammonium trichloro (dioxoethylene-O, O′) tellurate) is an important
hypervalent Te-based prodrug. Recently, we started a systematic investigation on AS101 …