The effect of the novel tellurium compound AS101 on autoimmune diseases
G Halpert, B Sredni - Autoimmunity reviews, 2014 - Elsevier
Tellurium is a rare element, which has been regarded as a non-essential trace element
despite its relative abundance in the human body. The chemistry of tellurium supports a …
despite its relative abundance in the human body. The chemistry of tellurium supports a …
Tracing tellurium and its nanostructures in biology
Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and
selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te …
selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te …
[HTML][HTML] p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium
L Wang, M Cano, JT Handa - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
As a signaling hub, p62/sequestosome plays important roles in cell signaling and
degradation of misfolded proteins. p62 has been implicated as an adaptor protein to …
degradation of misfolded proteins. p62 has been implicated as an adaptor protein to …
[HTML][HTML] Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells
X Chen, R Han, P Hao, L Wang, M Liu, M Jin… - Biomedicine & …, 2018 - Elsevier
Backgrounds Chronic inflammation in retinal pigment epithelial (RPE) cells is related to the
pathogenesis of retinal inflammatory blind causing diseases such as age-related macular …
pathogenesis of retinal inflammatory blind causing diseases such as age-related macular …
The natural carotenoid crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial …
G Di Emidio, G Rossi, I Bonomo… - Oxidative medicine …, 2017 - Wiley Online Library
Cancer therapies are associated with increased infertility risk due to accelerated
reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity …
reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity …
Screening of AS101 analog, organotellurolate (IV) compound 2 for its in vitro biocompatibility, anticancer, and antibacterial activities
Organotellurium compounds are being well researched as potential candidates for their
functional roles in therapeutic and clinical biology. Here, we report the in vitro anticancer …
functional roles in therapeutic and clinical biology. Here, we report the in vitro anticancer …
Illumination from light-emitting diodes (LEDs) disrupts pathological cytokines expression and activates relevant signal pathways in primary human retinal pigment …
Y Shen, C Xie, Y Gu, X Li, J Tong - Experimental eye research, 2016 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness in the aged
people. The latest systemic review of epidemiological investigations revealed that excessive …
people. The latest systemic review of epidemiological investigations revealed that excessive …
Medicinal hypervalent tellurium prodrugs bearing different ligands: a comparative study of the chemical profiles of AS101 and its halido replaced analogues
Ammonium trichloro (dioxoethylene-O, O′) tellurate (AS101) is a potent immunomodulator
prodrug that, in recent years, entered various clinical trials and was tested for a variety of …
prodrug that, in recent years, entered various clinical trials and was tested for a variety of …
Elucidation of tellurium biogenic nanoparticles in garlic, Allium sativum, by inductively coupled plasma-mass spectrometry
Y Tanaka, S Takada, K Kumagai, K Kobayashi… - Journal of Trace …, 2020 - Elsevier
Abstract Background Biosynthesis of Te nanoparticles may occur in higher plants exposed
to Te, as reported on microorganisms. However, unambiguous observations of the biogenic …
to Te, as reported on microorganisms. However, unambiguous observations of the biogenic …
[HTML][HTML] Unveiling the mechanism of activation of the Te (IV) prodrug AS101. New chemical insights towards a better understanding of its medicinal properties
Abstract AS101 (Ammonium trichloro (dioxoethylene-O, O′) tellurate) is an important
hypervalent Te-based prodrug. Recently, we started a systematic investigation on AS101 …
hypervalent Te-based prodrug. Recently, we started a systematic investigation on AS101 …