Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system

C Giaume, M Theis - Brain Research Reviews, 2010 - Elsevier
This review gives an overview of connexin expression in glial cells of the central nervous
system, the different modes of connexin action, including gap junctional channels and …

Astrocytic connexin43 channels as candidate targets in epilepsy treatment

L Walrave, M Vinken, L Leybaert, I Smolders - Biomolecules, 2020 - mdpi.com
In epilepsy research, emphasis is put on exploring non-neuronal targets such as astrocytic
proteins, since many patients remain pharmacoresistant to current treatments, which almost …

Hemolysis is a primary ATP-release mechanism in human erythrocytes

J Sikora, SN Orlov, K Furuya… - Blood, The Journal of …, 2014 - ashpublications.org
The hypothesis that regulated ATP release from red blood cells (RBCs) contributes to nitric
oxide-dependent control of local blood flow has sparked much interest in underlying release …

Carbenoxolone impairs LTP and blocks NMDA receptors in murine hippocampus

AN Chepkova, OA Sergeeva, HL Haas - Neuropharmacology, 2008 - Elsevier
Effects of the gap junction blocker carbenoxolone (CBX) on tetanus-and taurine-induced
long-term potentiation (LTP) were studied on Schaffer collateral–CA1 field excitatory …

[HTML][HTML] The metabolic and toxic acute effects of phloretin in the rat liver

FSI Da Silva, PFV Bizerra, MS Mito… - Chemico-Biological …, 2022 - Elsevier
The current study sought to evaluate the acute effects of phloretin (PH) on metabolic
pathways involved in the maintenance of glycemia, specifically gluconeogenesis and …

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma …

Y Yulyana, A Tovmasyan, IAW Ho, KC Sia… - Stem cell reviews and …, 2016 - Springer
Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat
due to its highly invasive nature and heterogeneity. Malignant brain tumor displays high …

Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury

HL Hellmich, DR Rojo, MA Micci, SL Sell, DR Boone… - PloS one, 2013 - journals.plos.org
Developing new pharmacotherapies for traumatic brain injury (TBI) requires elucidation of
the neuroprotective mechanisms of many structurally and functionally diverse compounds …

The harmful acute effects of clomipramine in the rat liver: impairments in mitochondrial bioenergetics

PFV Bizerra, FSI da Silva, EH Gilglioni, LF Nanami… - Toxicology Letters, 2023 - Elsevier
Clomipramine, a tricyclic antidepressant used to treat depression and obsessive-compulsive
disorder, has been linked to a few cases of acute hepatotoxicity. It is also recognized as a …

Development of chemosensitivity in neurons from the nucleus tractus solitarii (NTS) of neonatal rats

SC Conrad, NL Nichols, NA Ritucci, JB Dean… - Respiratory physiology …, 2009 - Elsevier
We studied the development of chemosensitivity during the neonatal period in rat nucleus
tractus solitarii (NTS) neurons. We determined the percentage of neurons activated by …

Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and …

S Dal Rhee, CH Kim, JS Park, WH Jung… - European Journal of …, 2012 - Elsevier
Carbenoxolone is the 3-hemisuccinate of glycyrrhetinic acid, the active principal of licorice
(Glycyrrhiza glabra). It was reported that carbenoxolone improved glucose tolerance with …