Context Androgen-deprivation therapy (ADT) is a key component of treatment for aggressive
and advanced prostate cancer, but it has also been associated with adverse effects on bone …

Osteoporosis is a skeletal disorder characterized by decreased mass and compromised
bone strength predisposing to an increased risk of fractures. Although idiopathic …

Background Testosterone treatment in men with hypogonadism improves bone density and
quality, but trials with a sufficiently large sample and a sufficiently long duration to determine …

There are three distinct areas of cancer management that make bone health in cancer
patients of increasing clinical importance. First, bone metastases are common in many solid …

Background Sipuleucel-T, an autologous active cellular immunotherapy, has shown
evidence of efficacy in reducing the risk of death among men with metastatic castration …

Importance As men age, they experience decreased serum testosterone concentrations,
decreased bone mineral density (BMD), and increased risk of fracture. Objective To …

Purpose: The summary presented herein represents Part II of the two-part series dedicated
to Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline discussing prognostic and …

Background Androgen-deprivation therapy is well-established for treating prostate cancer
but is associated with bone loss and an increased risk of fracture. We investigated the effects …

Purpose Androgen suppression therapy (AST) results in musculoskeletal toxicity that
reduces physical function and quality of life. This study examined the impact of a combined …

Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant
organs are a critical issue. However, how metastatic tumor cells become dormant and how …