[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance
R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …
mRNA are removed and protein-coding segments are assembled in diverse combinations …
Therapeutic targeting of splicing in cancer
SCW Lee, O Abdel-Wahab - Nature medicine, 2016 - nature.com
Recent studies have highlighted that splicing patterns are frequently altered in cancer and
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …
[HTML][HTML] RNA and disease
TA Cooper, L Wan, G Dreyfuss - Cell, 2009 - cell.com
Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-
binding proteins associated with them, which form ribonucleoprotein complexes (RNPs) …
binding proteins associated with them, which form ribonucleoprotein complexes (RNPs) …
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
A Karlas, N Machuy, Y Shin, KP Pleissner, A Artarini… - Nature, 2010 - nature.com
Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics,
represents a worldwide threat to public health. High mutation rates facilitate the generation …
represents a worldwide threat to public health. High mutation rates facilitate the generation …
The spliceosome as a target of novel antitumour drugs
S Bonnal, L Vigevani, J Valcárcel - Nature reviews Drug discovery, 2012 - nature.com
Several bacterial fermentation products and their synthetic derivatives display antitumour
activities and bind tightly to components of the spliceosome, which is the complex molecular …
activities and bind tightly to components of the spliceosome, which is the complex molecular …
[HTML][HTML] The CK1 family: contribution to cellular stress response and its role in carcinogenesis
U Knippschild, M Krüger, J Richter, P Xu… - Frontiers in …, 2014 - frontiersin.org
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …
major regulatory roles in many cellular processes including DNA-processing and repair …
Alternative splicing in prostate cancer
A Paschalis, A Sharp, JC Welti, A Neeb… - Nature reviews Clinical …, 2018 - nature.com
Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
M Bezzi, SX Teo, J Muller, WC Mok… - Genes & …, 2013 - genesdev.cshlp.org
The tight control of gene expression at the level of both transcription and post-transcriptional
RNA processing is essential for mammalian development. We here investigate the role of …
RNA processing is essential for mammalian development. We here investigate the role of …
[HTML][HTML] Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee …
V Deshmukh, AL O'Green, C Bossard, T Seo… - Osteoarthritis and …, 2019 - Elsevier
Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
Alternative splicing in disease and therapy
MA Garcia-Blanco, AP Baraniak, EL Lasda - Nature biotechnology, 2004 - nature.com
Alternative splicing is the major source of proteome diversity in humans and thus is highly
relevant to disease and therapy. For example, recent work suggests that the long-sought …
relevant to disease and therapy. For example, recent work suggests that the long-sought …