SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …

The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized
by club-like spikes that project from their surface, unusually large RNA genome, and unique …

Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin or ubiquitin-like gene
products, reverse the modification of proteins by a single ubiquitin (-like) protein, and …

This review focuses on the monophyletic group of animal RNA viruses united in the order
Nidovirales. The order includes the distantly related coronaviruses, toroviruses, and …

SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene
expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their …

SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the
antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like …

We report the discovery and optimization of a potent inhibitor against the papain-like
protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome …

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene
expression, including type I interferon production, by promoting host mRNA degradation and …

Replication of the genomic RNA of severe acute respiratory syndrome coronavirus (SARS-
CoV) is mediated by replicase polyproteins that are processed by two viral proteases …