AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …

Infection with the human immunodeficiency virus (HIV) is associated with a progressive
decrease in CD4 T-cell number and a consequent impairment in host immune defenses …

Objective To characterize immune phenotype and thymic function in HIV-1-infected adults
with excellent virologic and poor immunologic responses to highly active antiretroviral …

Objective: To describe the magnitude of immune restoration after long-term control of HIV-1
replication. Design: Prospective study of immune restoration in patients starting highly active …

Background: Immune reconstitution inflammatory syndrome (IRIS), also called immune
restoration disease, occurs in a subset of HIV-infected patients after the initiation of highly …

During HIV/SIV infection, there is widespread programmed cell death in infected and,
perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas–Fas …

The absence of immune defects that occurs in the syndrome of long-term nonprogressive
(LTNP) HIV infection offers insights into the pathophysiology of HIV-induced immune …

Loss of CD4+ T cells, the hallmark of HIV pathogenesis, was suggested to be partly due to
apoptosis. We recently reported that IFN-α produced by HIV-1-activated plasmacytoid …

Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected
macaques, whereas natural reservoir hosts exhibit limited disease and pathology. It is …

Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also
involved in the pathogenesis of many human diseases including human immunodeficiency …