[HTML][HTML] Exploring epigenetic modifications as potential biomarkers and therapeutic targets in glaucoma

E Tonti, R Dell'Omo, M Filippelli, L Spadea… - International Journal of …, 2024 - mdpi.com
Glaucoma, a complex and multifactorial neurodegenerative disorder, is a leading cause of
irreversible blindness worldwide. Despite significant advancements in our understanding of …

[HTML][HTML] MicroRNAs in Pancreatic Cancer: Advances in Biomarker Discovery and Therapeutic Implications

R Madadjim, T An, J Cui - International Journal of Molecular Sciences, 2024 - mdpi.com
Pancreatic cancer remains a formidable malignancy characterized by high mortality rates,
primarily attributable to late-stage diagnosis and a dearth of effective therapeutic …

[HTML][HTML] miR-6805-5p as a biomarker of cisplatin-induced nephrotoxicity in patients with head and neck cancer

NDG Torso, JCF Quintanilha, MA Cursino… - Frontiers in …, 2023 - frontiersin.org
Introduction: The standard treatment for head and neck squamous cell carcinoma (HNSCC)
is cisplatin chemoradiotherapy. One of the main treatment adverse reactions is …

[HTML][HTML] The TGFβ Induced MicroRNAome of the Trabecular Meshwork

C Doyle, B Callaghan, AW Roodnat, L Armstrong… - Cells, 2024 - mdpi.com
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex,
multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically …

Silencing circRUFY1 protects retinal ganglion cell injury in acute intraocular hypertension by activating the ERK pathway through miR-196a-5p/CALM3 axis

BB Li, SJ Li, W Tang, M Zeng - Molecular & Cellular Toxicology, 2024 - Springer
Background Neuroinflammation has been recognized as a key pathological event in acute
glaucoma. Medical treatment of acute glaucoma has mainly focused on lowering intraocular …

TGF-beta/OPTN/FOXC1/miR-200 axis regulates intraocular pressure dynamics in trabecular meshwork cells

ABM Reddy, C Sugali, NN Gajula, S Chava - bioRxiv, 2024 - biorxiv.org
Glaucoma is the second leading cause of irreversible blindness globally, with elevated
intraocular pressure (IOP) being its primary risk factor. Current therapeutic approaches, such …

miR-210 is essential to retinal homeostasis in fruit flies and mice

D Colaianni, F Virga, A Tisi, C Stefanelli, G Zaccagnini… - bioRxiv, 2024 - biorxiv.org
miR-210 is one of the most evolutionarily conserved microRNAs. Recent studies in
Drosophila melanogaster have unveiled that the absence of miR-210 leads to a progressive …

[PDF][PDF] Investigating the therapeutic efficacy and mechanism of action of microRNAs in ameliorating Diabetic wounds

S Paul - 2023 - ourarchive.otago.ac.nz
Diabetes mellitus is a chronic disease and is responsible for the development of several
complications, such as diabetic wounds. Diabetic wound healing is characterized by an …