Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal
GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Abstract In coronavirus disease 2019 (Covid-19) era, neuroinflammation may develop due
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
Design, synthesis, docking, DFT, MD simulation studies of a new nicotinamide-based derivative: in vitro anticancer and VEGFR-2 inhibitory effects
A nicotinamide-based derivative was designed as an antiproliferative VEGFR-2 inhibitor
with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket …
with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket …
Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools: a molecular …
Mycobacterium tuberculosis is the bacterial strain that causes tuberculosis (TB). However,
multidrug-resistant and extensively drug-resistant tuberculosis are significant obstacles to …
multidrug-resistant and extensively drug-resistant tuberculosis are significant obstacles to …
A Computational Approach to Elucidate the Interactions of Chemicals From Artemisia annua Targeted Toward SARS-CoV-2 Main Protease Inhibition for COVID-19 …
The inhibitory potential of Artemisia annua, a well-known antimalarial herb, against several
viruses, including the coronavirus, is increasingly gaining recognition. The plant extract has …
viruses, including the coronavirus, is increasingly gaining recognition. The plant extract has …
Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development …
An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …
[HTML][HTML] Bioassay-guided identification of potential Alzheimer's disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using …
Alzheimer's disease (AD) has become a major public health concern and the fifth major
cause of death among the aging population globally. In this study, the total phenols and …
cause of death among the aging population globally. In this study, the total phenols and …
Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of apigenin as an active compound
Background Wedelia chinensis has been reported as a folk medicine for the treatment of
different diseases including neurodegenerative disease. Although the plant has been …
different diseases including neurodegenerative disease. Although the plant has been …
In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy
IO Evbuomwan, OO Alejolowo, TC Elebiyo… - Journal of …, 2024 - Taylor & Francis
The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …
significantly threatens global health. This factor heightens the urgency to explore bioactive …
Proposing novel natural compounds against Alzheimer's disease targeting acetylcholinesterase
Alzheimer's disease (AD) is a neurodegenerative disorder considered as a global public
health threat influencing many people. Despite the concerning rise in the affected …
health threat influencing many people. Despite the concerning rise in the affected …
[PDF][PDF] In silico ADME-T and molecular docking study of phytoconstituents from Tithonia diversifolia (Hemsl.) A. Gray on various targets of diabetic nephropathy
OR Adianingsih, U Khasanah, KD Anandhy… - J Pharm Pharmacogn …, 2022 - academia.edu
Abstract Context: Tithonia diversifolia (Hemsl.) A. Gray has been known for treatment of
diabetes mellitus, yet its mechanism as anti-diabetic has not been defined. There are …
diabetes mellitus, yet its mechanism as anti-diabetic has not been defined. There are …