Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Coumarin derivatives were recently shown to constitute a totally new class of inhibitors of the
zinc metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1), being hydrolyzed within the CA …

In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the
first few hours after stroke, and the utility of current platelet aggregation inhibitors, including …

Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …

Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

A large series of 3-carboxamido-7-substituted coumarins have been synthesized and tested
in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory …

Hereditary deficiency of factor XII (Hageman factor) or factor XI, plasma proteases that
initiate the intrinsic pathway of coagulation, impairs thrombus formation and provides …

Aryne compounds are highly reactive intermediates that have been widely used in organic
synthesis.[1, 2] In recent years, studies on aryne-based reactions have achieved some …