Paracellular permeability and tight junction regulation in gut health and disease
Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …
Tight junction structure and function revisited
Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …
Contribution of the intestinal microbiome and gut barrier to hepatic disorders
DM Chopyk, A Grakoui - Gastroenterology, 2020 - Elsevier
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …
Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
The genetics of kidney stone disease and nephrocalcinosis
P Singh, PC Harris, DJ Sas, JC Lieske - Nature Reviews Nephrology, 2022 - nature.com
Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …
Tight junctions: from simple barriers to multifunctional molecular gates
C Zihni, C Mills, K Matter, MS Balda - Nature reviews Molecular cell …, 2016 - nature.com
Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …
organisms from the outside world. This requires the formation of tight junctions, selective …
The claudins: from tight junctions to biological systems
S Tsukita, H Tanaka, A Tamura - Trends in biochemical sciences, 2019 - cell.com
Claudins are cell–cell adhesion molecules located at the tight junctions (TJs) between cells
in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane …
in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane …
Cell biology of tight junction barrier regulation and mucosal disease
A Buckley, JR Turner - Cold Spring Harbor perspectives …, 2018 - cshperspectives.cshlp.org
Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …
selectively permeable barrier that supports nutrient absorption and waste secretion while …
[HTML][HTML] Magnesium in man: implications for health and disease
JHF De Baaij, JGJ Hoenderop… - Physiological …, 2015 - journals.physiology.org
Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …
role in supporting and sustaining health and life. As the second most abundant intracellular …
Tight junction proteins in gastrointestinal and liver disease
MB Zeisel, P Dhawan, TF Baumert - Gut, 2019 - gut.bmj.com
Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …