Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Uric acid, or more correctly (at physiological pH values), its monoanion urate, is traditionally
considered to be a metabolically inert end-product of purine metabolism in man, without any …

Pregnancy is a state of oxidative stress arising from increased placental mitochondrial
activity and production of reactive oxygen species (ROS), mainly superoxide anion. The …

Background—Serum uric acid (UA) could be a valid prognostic marker and useful for
metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF) …

A free radical is any species capable of independent existence that contains one or more
unpaired electrons. Free radical reactions have been implicated in the pathology of more …

The biochemical mechanisms behind skeletal muscle soreness and damage with muscular
overuse have remained unclear. Recently, however, a growing amount of evidence …

Background Chronic heart failure is associated with hyperuricaemia and elevations in
circulating markers of inflammation. Activation of xanthine oxidase, through free radical …

Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to
days. Identified mechanisms of postischemic neuronal injury include altered Ca2+ …

Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …

Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome.
Traditionally the high uric acid concentration in preeclampsia has been attributed solely to …