The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion
K Raedschelders, DM Ansley, DDY Chen - Pharmacology & therapeutics, 2012 - Elsevier
Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …
Towards the physiological function of uric acid
BF Becker - Free Radical Biology and Medicine, 1993 - Elsevier
Uric acid, or more correctly (at physiological pH values), its monoanion urate, is traditionally
considered to be a metabolically inert end-product of purine metabolism in man, without any …
considered to be a metabolically inert end-product of purine metabolism in man, without any …
Oxidative stress in the placenta
L Myatt, X Cui - Histochemistry and cell biology, 2004 - Springer
Pregnancy is a state of oxidative stress arising from increased placental mitochondrial
activity and production of reactive oxygen species (ROS), mainly superoxide anion. The …
activity and production of reactive oxygen species (ROS), mainly superoxide anion. The …
Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
SD Anker, W Doehner, M Rauchhaus, R Sharma… - Circulation, 2003 - Am Heart Assoc
Background—Serum uric acid (UA) could be a valid prognostic marker and useful for
metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF) …
metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF) …
Drug antioxidant effects: A basis for drug selection?
B Halliwell - Drugs, 1991 - Springer
A free radical is any species capable of independent existence that contains one or more
unpaired electrons. Free radical reactions have been implicated in the pathology of more …
unpaired electrons. Free radical reactions have been implicated in the pathology of more …
Biochemical mechanisms for oxygen free radical formation during exercise
B Sjödin, YH Westing, FS Apple - Sports medicine, 1990 - Springer
The biochemical mechanisms behind skeletal muscle soreness and damage with muscular
overuse have remained unclear. Recently, however, a growing amount of evidence …
overuse have remained unclear. Recently, however, a growing amount of evidence …
Uric acid in chronic heart failure: a marker of chronic inflammation
Background Chronic heart failure is associated with hyperuricaemia and elevations in
circulating markers of inflammation. Activation of xanthine oxidase, through free radical …
circulating markers of inflammation. Activation of xanthine oxidase, through free radical …
[HTML][HTML] Molecular mechanisms of ischemic neuronal injury
RW Neumar - Annals of emergency medicine, 2000 - Elsevier
Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to
days. Identified mechanisms of postischemic neuronal injury include altered Ca2+ …
days. Identified mechanisms of postischemic neuronal injury include altered Ca2+ …
The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction
A Meneshian, GB Bulkley - Microcirculation, 2002 - Wiley Online Library
Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …
Hyperuricemia and xanthine oxidase in preeclampsia, revisited
A Many, CA Hubel, JM Roberts - American journal of obstetrics and …, 1996 - Elsevier
Hyperuricemia is associated with the severity of preeclampsia and with fetal outcome.
Traditionally the high uric acid concentration in preeclampsia has been attributed solely to …
Traditionally the high uric acid concentration in preeclampsia has been attributed solely to …