Selection strategies for anticancer antibody discovery: searching off the beaten path

D Sánchez-Martín, MD Sørensen, S Lykkemark… - Trends in …, 2015 - cell.com
Antibody-based drugs represent one of the most successful and promising therapeutic
approaches in oncology. Large combinatorial phage antibody libraries are available for the …

Antibody identification for antigen detection in formalin-fixed paraffin-embedded tissue using phage display and naive libraries

C Mairaville, P Martineau - Antibodies, 2021 - mdpi.com
Immunohistochemistry is a widely used technique for research and diagnostic purposes that
relies on the recognition by antibodies of antigens expressed in tissues. However, tissue …

Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections

KMJ Sørensen, T Meldgaard, CJ Melchjorsen… - BMC cancer, 2017 - Springer
Background One of the hallmarks of cancer is an altered energy metabolism, and here,
mitochondria play a central role. Previous studies have indicated that some mitochondrial …

Selection of cell‐type specific antibodies on tissue‐sections using phage display

SA Larsen, T Meldgaard, S Lykkemark… - Journal of cellular …, 2015 - Wiley Online Library
With the advent of modern technologies enabling single cell analysis, it has become clear
that small sub‐populations of cells or even single cells can drive the phenotypic appearance …

Raising an antibody specific to breast cancer subpopulations using phage display on tissue sections

SA Larsen, T Meldgaard… - Cancer genomics & …, 2016 - cgp.iiarjournals.org
Background/Aim: Primary tumors display a great level of intra-tumor heterogeneity in breast
cancer. The current lack of prognostic and predictive biomarkers limits accurate stratification …

Selection strategies for tissue-specific antibody identification using phage display and naïve libraries

C Mairaville, P Martineau - 2020 - preprints.org
Immunohistochemistry is a widely used technique for research and diagnostic purposes that
relies on the recognition by antibodies of antigens expressed in tissues. However, tissue …

Developing Affimers for the detection of biomarkers in cancer

DA Al-Qallaf - 2018 - etheses.whiterose.ac.uk
Biomarkers are molecules present in the patients' samples. They are used to detect the
presence of a disease or an infection. An array of laboratory tools is used to monitor …

[引用][C] Selection Strategies for Tissue-Specific Antibody Identification Using Phage Display and Naïve Libraries

CMP Martineau - Preprints, 2020 - MDPI AG